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KMID : 0370220230670010008
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Yakhak Hoeji
2023 Volume.67 No. 1 p.8 ~ p.14
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Effect of Savinin to Inhibit RANKL-induced Osteoclast Differentiation
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Shin Han-Byeol
Lee Yong-Jin
Lee Min-A
Son Young-Jin
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Abstract
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Osteoporosis is a disease in which bone density is decreased and fractures occur easily due to externalenvironment. The treatment of osteoporosis is important to prevent bone loss and to suppress the formation of osteoclastsinvolved in bone resorption. Osteoclasts, which are multinucleated cells, are greatly increased and overactivated in bonediseases including osteoporosis and rheumatoid arthritis. In this study, the effect of savinin on osteoclast differentiation byRANKL was investigated. Savinin significantly inhibited RANKL-induced osteoclast differentiation by inhibiting thetranscriptional and translational expression of NFATc1, an essential component of RANKL-mediated osteoclast formation. Inaddition, mRNA expressions of OSCAR, DC-STAMP, and CTSK related to osteoclast differentiation and function weresuppressed. Inhibition of osteoclast activity was verified through bone resorptive assay. Therefore, it is confirmed that savinininhibits osteoclast differentiation, so it has the potential to be used as a therapeutic agent for the treatment of osteoporosis.
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KEYWORD
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Bone, Osteoporosis, Osteoclast, RANKL, NFATc1, Savinin
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